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5-Androstan-17β-ol-3-one in its free or in its propionate form was injected systemically (125 µg/day/rat) into sexually experienced, adult, castrated, male rats. These compounds were ineffective in activating masculine behaviour patterns, despite having measurable effects on body weight, seminal vesicle weight and penile morphology. The propionate form also had strong anti-gonadotrophic properties, since when it was injected for 6 days into intact, immature, male rats it significantly reduced testicular weight.

In contrast, testosterone propionate (125 µg/day/rat) restored male sexual behaviour to the levels found before castration when injected systemically. Testosterone propionate also affected body weight, seminal vesicle weight, penile morphology and the testicular weight of immature males. These effects may have been due in part to conversion of testosterone to 5-androstan-17β-ol-3-one, but this metabolic step does not seem to be obligatory for activation of male sexual behaviour in rats.

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				M. J. Baum and J. T. M. Vreeburg Copulation in Castrated Male Rats following Combined Treatment with Estradiol and Dihydrotestosterone Science, October 19, 1973; 182(4109): 283 - 285. [Abstract] [PDF]