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Department of Anatomy and Embryology, University of Amsterdam, Mauritskade 61, Amsterdam, The Netherlands

(Received 30 January 1975)

To test the usefulness of a recently described bioassay of progestational activity (Madjerek, 1972), based on the production of traumatic decidual reaction in immature female rats, a series of agents, known to have some progestational effects in other tests, was investigated for their short- and long-lasting activities.

Immature female rats of an inbred commercial Wistar strain were used. Daily administration of a substance was begun 1 day before uterine traumatization and continued once daily for 5 days. To test prolonged activity, the substance was given in one single injection 1 day before traumatization. On the 5th day after traumatization, the rats were killed and the uteri removed. The decidual reaction (DR) was scored macro- and microscopically according to an arbitrary scale (1–4) and expressed as the deciduoma index (DI), arrived at by dividing