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Progestational agents were studied for their effects on collagenolytic activity and loss of collagen and wet weight from the involuting post-partum rat uterus. Administration of very large doses of progesterone (80–150 mg/day) significantly retarded uterine involution and loss of collagen. This was accompanied by a significant reduction in uterine collagenolytic activity. By 72 h post partum, uteri of rats treated with 150 mg progesterone/day had wet weights 30% above, collagen 85% above, and collagenolytic activity 45% below, those of the control uteri.

Similar effects were produced by 17-acetoxy-6-methylprogesterone at the same dosage levels. However, the progestational agent 6-chloro-17-acetoxypregna-4,6-diene-3,20dione acetate had no effect in this system.