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Journal of Endocrinology (1975) 66, 407-412    DOI: 10.1677/joe.0.0660407
© 1975 Society for Endocrinology
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THE SYNERGISTIC ACTION OF {alpha}-MELANOCYTE-STIMULATING HORMONE AND TESTOSTERONE ON THE SEBACEOUS, PROSTATE, PREPUTIAL, HARDERIAN AND LACHRYMAL GLANDS, SEMINAL VESICLES AND BROWN ADIPOSE TISSUE IN THE HYPOPHYSECTOMIZED-CASTRATED RAT

 F. J. EBLING, ERIKA EBLING, VALERIE RANDALL and J. SKINNER

{alpha}-Melanocyte-stimulating hormone was shown to act synergistically with testosterone to stimulate the sebaceous, prostate and preputial glands and the seminal vesicles in hypophysectomized-castrated rats. The sebaceous glands differed from the other three organs in that {alpha}-MSH not only acted synergistically, but also had a significant effect which was independent of the presence of exogenous testosterone. The response of the brown adipose tissue to testosterone, considerably reduced by hypophysectomy, was not restored by {alpha}-MSH. The Harderian and lachrymal glands were also pituitary-dependent and their weights in hypophysectomized-castrated rats were not restored by {alpha}-MSH.






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Copyright © 1975 by the Society for Endocrinology.