HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by VISSER, T. J. Articles by BIRKENHÄGER, J. C. Search for Related Content PubMed Articles by VISSER, T. J. Articles by BIRKENHÄGER, J. C.

Department of Internal Medicine III and Clinical Endocrinology, Medical Faculty, Erasmus University, Rotterdam, and * Laboratory ofEndocrinological Chemistry, Municipal Hospital 'Bergweg', Rotterdam, The Netherlands

(Received 2 June 1975)

The availability of synthetic human parathyroid hormone (hPTH) fragments (Andreatta, Hartmann, Jöhl, Kamber, Maier, Riniker, Rittel & Sieber, 1973; Tregear, Van Rietschoten, Greene, Niall, Keutmann, Parsons, O'Riordan & Potts, 1974) has enabled the production of region specific antibodies and thus the development of region specific radioimmunoassays (RIA). This is particularly meaningful with respect to the heterogeneity of immunoreactive forms of PTH in the circulation (Arnaud, Goldsmith, Bordier, Sizemore, Larsen & Gilkinson, 1974). The peptides were synthesized according to the sequences proposed for the first 34 amino acids by Brewer, Fairwell, Ronan, Sizemore & Arnaud (1972) (referred to as 1–34 hPTH-B) and Niall, Sauer, Jacobs, Keutmann, Segre, O'Riordan, Aurbach & Potts (1974) (1–34 hPTH-N), which differ in positions 22, 28 and 30.

Two