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Section of Pharmacology, Academic Division of Medicine and *Field Laboratories, The University, Sheffield, S102TN

(Received 8 July 1975)

The McKenzie (1958) bioassay remains the principal tool for studying the long-acting thyroid stimulator (LATS) and LATS-protector (LATSP), although radioreceptor binding assays are being developed (Manley, Bourke & Hawker, 1974; Smith & Hall, 1974). A dog biscuit met the low-iodine requirements until 1974, when batches contained sufficient iodine to make them unsuitable for use in this bioassay. Bread contains negligible iodine, unless iodated dough conditioner is added (London & Vought, 1965). Thus an investigation was made of the suitability of bread for use in the McKenzie bioassay.

Female, white Swiss mice were bred as described by Loy & Broadhead (1968), the colony being fed on pasteurized breeding diet (Oxoid Ltd). Mice were weaned at 4 weeks, fed on diet 86 (Oxoid Ltd) until body weights were 15–20 g (i.e. usually for 1–2 weeks),