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Biochemistry and Biophysics Section, University of Connecticut, Storrs, Connecticut 06268, U.S.A.

(Received 2 September 1976)

Polycystic ovaries can be induced by a series of 20 daily injections of human chorionic gonadotrophin (HCG; 10 i.u./day, s.c.) in rats previously made hypothyroid with 0·5% 2-thiouracil in their feed (Leathem, 1958). Slices of polycystic ovaries convert glucose stoichiometrically to lactate under aerobic conditions, while slices of normal or luteinized (HCG) ovaries or those from hypothyroid rats convert less than 50% of the glucose consumed to lactate, under similar conditions (Surwilo & Doeg, 1973). High rates of aerobic glycolysis, as seen in polycystic ovarian slices, are also characteristic of a variety of tumours (Aisenberg, 1961). Some of these tumours have low activities of one of the 'shuttle' enzymes involved in the transfer of reducing equivalents from the cytosol to the mitochondria (Boxer & Devlin, 1961; Criss, 1973), and, thus, pyruvate reduction to lactate provides