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Department of Pharmacology, Research and Medical Affairs Division, Parke, Davis & Company, Ann Arbor, Michigan 48106, U.S.A.

(Received 22 June 1976)

Leicht, Birò & Weinges (1974) recently reported that infusion of salmon calcitonin into 11 human subjects significantly inhibited luteinizing hormone (LH) and thyrotrophin (TSH) secretion induced by LH releasing hormone (LH-RH) and thyrotrophin releasing hormone (TRH) respectively. Basal secretion of these two pituitary hormones was unaffected. Since serum Ca²⁺ concentrations were not changed significantly, Leicht et al. (1974) postulated that calcitonin might act directly on the secretory cells of the pituitary gland, possibly by altering Ca²⁺ fluxes at the level of the cell membrane. To test the hypothesis of a direct action of calcitonin on pituitary cells, we examined the effect of synthetic salmon calcitonin on LH and TSH release in unstimulated, and LH-RH- and TRH-stimulated anterior pituitary cell cultures.

Pooled anterior pituitary glands from dioestrous Charles-River