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Departments of Pathology, Medicine, and Physiology and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195, U.S.A.

(Received 1 September 1976)

Somatostatin (somatotrophin release inhibiting factor) antagonizes the secretion of somatotrophin (Brazeau, Vale, Burgus, Ling, Butcher, Rivier & Guillemin, 1973), insulin (Alberti, Christensen, Christensen, Hansen, Iversen, Lundbaeck, Seyer-Hansen & Orskov, 1973), thyrotrophin (Hall, Besser, Schally, Coy, Evered, Goldie, Kastin, McNeilly,Mortimer,Phenekos, Tunbridge & Weightman, 1973), glucagon (Iversen, 1974; Koerker, Ruch, Chideckel, Palmer, Goodner, Ensinck & Gale, 1974; Mortimer, Tunbridge, Carr, Yeomans, Lind, Coy, Bloom, Kastin, Mallinson, Besser, Schally & Hall, 1974), gastrin (Bloom, Mortimer, Thorner, Besser, Hall, Gomez-Pan, Roy, Russell, Coy, Kastin & Schally, 1974), gastric acid (Barros D'Sa, Bloom & Baron, 1975; Gomez-Pan, Reed, Albinus, Shaw, Hall, Besser, Coy, Kastin & Schally, 1975) and pepsin (Gomez-Pan et al. 1975) but appears to have no effect on secretion of follicle-stimulating hormone, luteinizing hormone, prolactin, corticotrophin, corticosteroids (Hall et al. 1973),