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The endocrine pancreas of foetuses and newborn rats of experimental diabetic mothers showed morphological and ultrastructural changes. Islet hypertrophy and β cell hyperplasia were constantly present, but the β cells of foetuses of severely diabetic mothers were degranulated. The ultrastructural changes indicated hyperfunction in the β cells of foetuses of experimental diabetic mothers. The morphological changes mentioned were similar to those seen in human diabetic pregnancy.