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In post-absorptive rats in a 20 °C environment, bilateral hind-limb ischaemia decreased the plasma growth hormone concentration below the very wide range found in control rats. Injection of sodium pentobarbitone increased the concentration in both control and injured rats but did not eliminate the difference between them. A 20% dorsal scald also decreased the variability of plasma growth hormone concentration but did not reduce it below the normal range. Thus growth hormone is probably not responsible for the insulin resistance seen in the severely injured rat. The plasma corticosterone concentration markedly increased after both injuries but was not altered by pentobarbitone.