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Department of Pathophysiology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

(Received 8 December 1976)

Since it has been reported that prostaglandin synthesis occurs in rat (Ellis, Johnson & Hargrove, 1972; Carpenter, 1974) and rabbit testes (Christ & van Dorp, 1972), we have studied the 17-oxosteroid secretory response of the testis to human chorionic gonadotrophin (HCG) in dogs pretreated with aspirin, a potent inhibitor of prostaglandin synthesis (Vane, 1971).

Fourteen male mongrel dogs weighing between 7·8 and 19·8 kg were used. Each animal was anaesthetized by i.v. injection of sodium pentobarbitone (25 mg/kg) and the left spermatic vein was cannulated by the lumbar route (Yamashita, 1966). After spermatic venous cannulation, aspirin (20 or 200 mg/kg) was given with 200 ml distilled water into the stomach through an oesophageal catheter. Controls received 200 ml distilled water only. Three hours after the administration of aspirin, 1 ml 0·9% NaCl solution