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Department of Dairy Husbandry, University of Missouri-Columbia, Columbia, Missouri 65201, U.S.A.

(Received 14 December 1976)

Several adenohypophysial hormones have been found in cerebrospinal fluid (CSF), thus indicating that the expected blood-CSF permeability barrier (Davson, 1967; Levin & Tradatti, 1976) may not be present for these hormones. Significant quantities of prolactin (2–26 ng/ml) are present in CSF from the cisterna magna of rats and may function in short-loop feedback control of pituitary secretion (Clemens & Sawyer, 1974). In man, low levels of somatotrophin, adrenocorticotrophin, thyrotrophin, prolactin and luteinizing hormone (LH) are present in lumbar CSF from non-endocrine patients while much higher levels occur in patients with pituitary tumours (Linfoot, Garcia, Wei, Fink, Sarin, Born & Lawrence, 1970; Kleerekoper, Donald & Posen, 1972; Kendall, Seaich, Allen & Vanderlaan, 1975; Jordon, Kendall, Seaich, Allen, Paulsen, Kerber & Vanderlaan, 1976). Levina (1972) reported finding both follicle-stimulating hormone and LH in lateral ventricular CSF from