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Instituto di Zoologia, Università di Napoli, Via Mezzocannone 8, Napoli, Italy

(Received 31 December 1976)

In the lizard Lacerta s. sicula sex steroids induce the synthesis of avidin in the oviduct in vivo (Botte, Segal & Koide, 1974). We report here evidence that these effects could be mediated, in vivo and in vitro, by RNA.

Adult female Lacerta s. sicula were maintained in terraria at 28 °C, and under a naturalphotoperiod. The lizards were ovariectomized and used 15 days after the operation. For the RNA preparation, three groups of ovariectomized females, each comprising 40 animals, were treated as follows: Group 1, four doses of 50 µg oestradiol dipropionate in 0·05 ml almond oil (every 3 days), administered intramuscularly; Group 2, treated with oestradiol as in Group 1, but only three times; on the fourth treatment given 0·5 mg progesterone in 0·05 ml almond oil; Group 3, injected with almond