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Department of Physiology, Nagasaki University School of Medicine, Nagasaki, Japan

(Received 5 January 1977)

A systemic administration of histamine to intact dogs markedly increases the adrenocortical secretion (Suzuki, Hirai, Yoshio, Kurouji & Yamashita, 1963; Papp, Stark, Acs & Varga, 1964; Asano, 1966; Katsuki, Ito, Watanabe, Iino, Yuji & Kondo, 1967; Tanigawa, 1967; Yamashita, Shimizu, Mieno & Kawao, 1973). This effect was found to be completely abolished by hypophysectomy (Asano, 1966). In the experiments by Tanigawa (1967), however, a slight increase in adrenocortical secretion in response to histamine was observed in some hypophysectomized dogs. In the present work a direct adrenocortical stimulatory effect of histamine was examined by evaluating the adrenal secretion of cortisol and corticosterone in response to histamine in hypophysectomized dogs.

Thirteen mongrel male dogs weighing 10·0–16·8 kg were used; four of them were intact, and the others were hypophysectomized. Under sodium pentobarbitone (25 mg/kg, i.v.) anaesthesia, hypophysectomy was