HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by GOLDSTEIN, R. Articles by PAVEL, S. Search for Related Content PubMed Articles by GOLDSTEIN, R. Articles by PAVEL, S.

Institute of Endocrinology, Bucharest, Rumania

(Received 29 March 1977)

The mammalian pineal gland contains (Pavel, 1965) and synthesizes (Pavel, Goldstein, Ghinea & Calb, 1977) the nonapeptide arginine-vasotocin (AVT). Since luteinizing hormone releasing hormone (LH–RH), thyrotrophin releasing hormone (TRH) and growth hormone release-inhibiting hormone (somatostatin, SRIF) have now been localized not only in the brain, but also in the pineal gland (White, Hedlund, Weber, Rippel, Johnston & Wilber, 1974; Pelletier, Le Clerc, Dube, Labrie, Puviani, Arimura & Schally, 1975), we investigated the effects of these peptides on the release of AVT into the cerebrospinal fluid (CSF) of cats.

Intracarotid injections of 0·1 µg LH-RH, TRH (Hoechst, Frankfurt), SRIF (Serono, Rome) or oxytocin (Syntocinon, Sandoz Ltd, Basel) in 0·5 ml saline were given to urethane-anaesthetized male cats weighing 3–4 kg. Controls received an equal volume of saline only. The pineal glands were removed 60 min after the injections, quickly homogenized, and extracted