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Wolfson Laboratory for Research in Gerontology, Department of Zoology, University of Hull, Hull, HU6 7RX

(Received 20 June 1977)

A relative lack of adrenocortical responsiveness to stress has been described in the rat during the period from day 2 to about day 16 of neonatal life (Schapiro, Geller & Eiduson, 1962; Levine, Glick & Nakane, 1967; Corte & Yasumura, 1975) and the reports to date seem to implicate a lack of response of the pituitary gland as the primary cause (Zarrow, Philpott & Denenberg, 1968; Donovan, 1970; Corte & Yasumura, 1975). Since very little work has been done on the response of the pituitary gland to stress in the neonatal rat, the present study was undertaken.

Female Sprague–Dawley rats weighing 300 g were housed at 22 °C with a light : darkness cycle of 12 : 12 h. Mated female rats were isolated on day 1 of pregnancy, and after