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Johnson Space Center, National Aeronautics and Space Administration, Houston, Texas 77058, U.S.A.

(Received 23 May 1977)

The levels of certain corticosteroids in the plasma do not necessarily change in parallel in response to treatment with adrenocorticotrophin (ACTH; Kolanowski, Pizarro & Crabbé, 1975) or low sodium diets (Vagnucci, McDonald, Drash & Wong, 1974). We report here the effect of controlled exercise on the levels of cortisol, corticosterone, cortisone and 11-deoxycortisol in the plasma of six men. (Informed consent was obtained from the participants; NASA adheres to the recommendations of human investigation taken from the Medical Research Council Report of 1962/63.)

Six men aged 31–50 years and familiar with the exercise régime rested supine for 1 h, rode a bicycle ergometer in the upright position for 16 min and then rested for 2 h. The exercise intensity was less than 85% of the maximum aerobic power (V_O2 max). During the first 10

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