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Schweizerisches Forschungsinstitut, Medizinische Abteilung, 7270 Davos, Switzerland and *Roche Diagnostica, 4133 Schweizerhalle, Switzerland

(Received 18 July 1977)

Administration of glucocorticoids can influence immune responses and their generally inhibitory effects vary with the animal species, the dose and the mode of administration (Claman, 1975). In view of this, it is reasonable to expect that glucocorticoids are involved in immunoregulation and if so, that the immune response itself should influence the levels of glucocorticoids. Previous studies (Besedovsky, Sorkin, Keller & Müller, 1975; Besedovsky & Sorkin, 1977) have shown a two- to threefold increase in the levels of corticosteroids in the blood, coinciding with the peak concentration of antibody-producing cells in the spleen after immune stimulation of rats and mice. The present communication reports that in a different immune response model, that of skin-graft rejection, the level of corticosterone in the blood differs from the levels in autografted and other control groups.

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