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Departments of Physiology and Pathology, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan

(Received 31 October 1977)

The important role of the kidney in the degradation and excretion of insulin has recently been reviewed (Rubenstein & Spitz, 1968; Rubenstein, Mako & Horwitz, 1975). The kidney functions with a wide margin of safety but the minimum functional renal mass required for the effective elimination of insulin is not known. The present report deals with the effects of total and five-sixths nephrectomy on the concentrations of insulin and glucose in the blood. The effects of uraemia itself, produced by bilateral ureteric ligation, have also been studied.

Albino rats of the Wistar strain (mean weight 232 ± 5 (S.E.M.) g) were used. Except for ten female rats included in the acutely uraemic group, the remainder of the animals were male. The subsequent operations were performed under open diethyl ether anaesthesia