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M.R.C. Unit of Reproductive Biology, 2 Forrest Road, Edinburgh, EHI 2QW

(Received 31 October 1977)

Exposure to testosterone during development masculinizes the genitalia and behaviour of ewes (Clarke, Scaramuzzi & Short, 1976a; Clarke, 1977) and causes ovulatory failure (Clarke, Scaramuzzi & Short, 1977). Androgenized ewes do not release luteinizing hormone (LH) after oestrogen treatment during anoestrus (Clarke, Scaramuzzi & Short, 1976b). These experiments were performed to determine the site of action (hypothalamus or anterior pituitary gland) of prenatally administered androgens in blocking the preovulatory release of LH.

Finnish Landrace x Dorset Horn ewes were used in their second breeding season after exposure to testosterone between days 30 and 80 (D30–80, n = 6), 50 and 100 (D50–100, n = 1), 70 and 120 (D70–120, n = 6) or 90 and 140 (D90–140, n = 5) of prenatal life (Clarke et al. 1976a). Eight normal ewes served as controls. To facilitate