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First Department of Internal Medicine, Kagoshima University, Medical School, Kagoshima 890, Japan

(Received 13 December 1977)

The role of brain noradrenaline in the regulation of pituitary-adrenocortical function is controversial. Ganong (1972) suggested that the central noradrenergic system inhibits the secretion of adrenocorticotrophin, but it has also been shown (Kumeda, Uchimura, Kawabata, Maeda, Okamota, Kawa & Kanehisa, 1974) that a drastic reduction in the hypothalamic noradrenaline content, resulting from intraventricular administration of 6-hydroxydopamine, has no effect on the basal levels of corticosterone in rat plasma and adrenal tissue. The stress response is also not affected, nor is the suppressive effect of dexamethasone on the plasma and adrenal concentrations of corticosterone. Almost identical results have been reported by Cuello, Shoemaker & Ganong (1974) and Kaplanski, van Delft, Nyakas, Stoof & Smelik (1974), and Cuello et al. (1974) suggested the possibility of denervation hypersensitivity developing as a result of intraventricular administration of 6-hydroxydopamine.