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Within some 14 h of treatment with oestradiol benzoate (5 µg), the intra-uterine pressure cycles in ovariectomized puerperal rats were almost abolished. However, treatment with 600 µg actinomycin D 30 min before the administration of oestradiol benzoate interfered significantly with the inhibition of uterine mechanical activity during the following 14 h. Treatment of rats with actinomycin D alone produced no significant fall in the frequency of pressure cycles. These results suggest that oestrogen inhibits myometrial activity in the rat through a mechanism which involves the synthesis of protein.