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Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53706, U.S.A.

(Received 25 January 1978)

Diurnal variations in the adrenal secretion of glucocorticoids have been described in a wide range of species. Among primates, most attention has been devoted to man (e.g. Krieger, 1970; Rose, Kreuz, Holaday, Sulak & Johnson, 1972), although the secretion of cortisol in the male rhesus monkey has also been examined (e.g. Michael, Setchell & Plant, 1974; Holaday, Meyerhoff & Natelson, 1977). We present here a report of circadian variations in the concentration of cortisol in the plasma throughout the menstrual cycle of the female rhesus monkey.

Three intact female rhesus monkeys (Macaca mulatta) were adapted to chronic restraint in primate chairs for several months. After confirmation of normal menstrual cycles, a chronic indwelling catheter (Silastic Medical Grade Tubing, 20-gauge, Dow Corning) was inserted. The catheter was placed into the right atrium via the internal

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