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The intestinal absorption of calcium has been studied in conscious, unstressed pigs, using a modification of the double isotope technique. The oral administration of betamethasone (1 mg/day) to four pigs (25–33 kg) for 4 weeks reduced the calcium absorption coefficient, calculated after the intravenous and oral administration of ⁴⁷Ca²⁺, by a mean value of 66%. The oral administration of 1-hydroxycholecalciferol (2 µg/day) in combination with betamethasone (1 mg/day) for a further 4 weeks returned the absorption coefficient to the control value.