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Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, U.S.A.

(Received 13 February 1978)

McConaghey & Sledge (1970) first demonstrated the production of somatomedin after perfusion of livers from normal rats with growth hormone (GH). Subsequent work has firmly established that the liver is an important site of somatomedin production and that GH plays an active role in this process (McConaghey, 1972; Uthne & Uthne, 1972; Phillips, Herrington, Karl & Daughaday, 1976), although little is known concerning its mechanism of action. Initially, several mechanisms, which can be discriminated in part by the requirement for active protein synthesis, appear possible. One of these states that GH, or perhaps a catabolite of it, stimulates the liver to synthesize somatomedin de novo and hence agents which inhibit protein synthesis could abolish the effects of GH on somatomedin production. The experiments reported here represent our initial attempts to test this