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Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH

(Received 23 February 1978)

In addition to its well-known peripheral actions, angiotensin II has been implicated in central nervous mechanisms concerned with the modulation of blood pressure, drinking, the release of antidiuretic hormone (ADH) and the secretion of adrenocorticotrophin (ACTH; see Severs & Daniels-Severs, 1973). The receptors responsible for mediating these central effects are both central and peripheral in relation to the blood–brain barrier. Because angiotensin II does not cross this barrier rapidly (Volicier & Loew, 1971), the physiological significance of the receptive sites for angiotensin II which lie on the central side of the barrier (e.g. in the mid-brain peri-aqueductal grey matter and the supraoptic nucleus of the hypothalamus) is unclear.

Recently, an independent iso-renin-angiotensin system has been demonstrated in the central nervous system (for review see Ganten, Hutchinson, Schelling, Ganten & Fisher, 1976)