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Journal of Endocrinology (1978) 79, 147-148    DOI: 10.1677/joe.0.0790147
© 1978 Society for Endocrinology

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EFFECTS OF HIGH ALTITUDE ON ENDOCRINE FUNCTION IN THE SHERPAS OF NEPAL

C. R. M. BANGHAM and P. H. HACKETT

*National Institute for Biological Standards and Control, Holly Hill, London, NW3 6RB and {ddagger}Himalayan Rescue Association, P.O. Box 283, Kathmandu, Nepal

(Received 23 May 1978)

There is demographic evidence from studies in the Andes (James, 1966; Heer, 1967; Abelson, 1976) for lower fertility in high-altitude dwellers than in moderate- or low-altitude dwellers. In the Sherpas of Nepal, the completed fertility rate at high altitude (about 6·0) is appreciably less than that at lower altitudes (8·5; C. R. M. Bangham & J. M. Sacherer, unpublished observations). However, the physiological reasons (if any) for such a difference are obscure. The present study was carried out to test the hypothesis that such a fertility difference (between low- and high-altitude dwellers) is reflected in different serum concentrations of reproductive hormones.

Sampling was carried out at altitudes of 4240 m in Khumbu, 2670 m in Pharak (south of Khumbu) and 1460 m in Kathmandu; the







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