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Université de Rennes, Laboratoire de Physiologie des Régulations, UER des Sciences Biologiques, 35031 Rennes Cedex, France

(Received 3 May 1978)

The results described by Naftolin, Ryan, Davies, Reddy, Flores, Petro, White, Takaoka & Wolin (1975) and Moguilevsky, Scacchi & Rubinstein (1977) indicate that the aromatization of androgens to oestrogens during the neonatal period provides a probable route of action for the testicular androgens. It is also thought that during this critical period, the conversion of androgens to oestrogens is involved in regulation of the hepatic and adrenal enzymes that metabolize steroid hormones (De Moor, Verhoeven & Heyns, 1973; Goldman, Gustafsson & Stenberg, 1974; Gustafsson & Stenberg, 1974). There is considerable evidence that androgens inhibit the secretion of luteinizing hormone (LH) when administered to immature and mature male rats immediately after castration (Mahesh, Muldoon, Eldridge & Korach, 1975; Moger, 1976; Shin & Howitt, 1976). The purpose of the present investigation was