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Service d'Explorations Métaboliques, Hôpital de la Conception, 13385 Marseille Cedex 4, France

(Received 24 July 1978)

It has recently been shown that ethynyl oestradiol markedly decreases lipase activity in the liver (Valette, Verine, Salers & Boyer, 1977). These observations, along with reports of oestrogen receptors in the liver (Chamness, Costlow & McGuire, 1975) suggest that oestrogens exert considerable influence over the hepatic metabolism of lipids. Previous investigations (DeLorimier, Gordon, Lowe & Carbone, 1965; Gallagher, Mueller & Kappas, 1966) have suggested that the extent of the hepatic changes could be correlated with the molecular nature of the hormonal compound and might depend particularly on the 17-alkyl-substituted group in synthetic oestrogens. The influence of the ethynyl function in the 17-position of oestradiol-17β on the oestrogen-induced changes observed in hepatic lipases and serum levels of triglycerides has therefore been examined.

Adult female Sprague–Dawley rats (220–240 g) were allowed free access to food and