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Extrathyroidal tissues of the rat were labelled to steady state by prolonged continuous intravenous infusion of ¹²⁵I-labelled thyroxine (T₄) or tri-iodothyronine (T₃). Labelled iodocompounds extracted from various tissues were analysed by thin-layer chromatography.

Significant amounts of labelled T₃ were found in all tissues examined after infusion of [¹²⁵I]T₄, confirming that conversion of T₄ to T₃ occurs in extrathyroidal tissues of the rat. Faecal excretion of labelled T₃ after [¹²⁵I]T₄ infusion provided an assessment of the extent of extrathyroidal conversion: about a third of the T₄ was metabolized by this pathway. Extrathyroidal conversion was independently estimated to account for about a third of the total production of T₃.

The site of extrathyroidal conversion was established by comparing the distributions of labelled T₃ after the two types of infusion: kidney and liver were both prominent sites of conversion of T₄ to T₃.

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				T. T. Nguyen, K. A. Mol, and J. J. DiStefano III Thyroid hormone production rates in rat liver and intestine in vivo: a novel graph theory and experimental solution Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E171 - E181. [Abstract] [Full Text] [PDF]