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Newborn Sprague–Dawley rats of both sexes were treated with 28 µg thyroxine (T₄) daily for the first week of life. At the age of 80 days, the secretion rate of sebum was measured from the amount of skin-surface lipids extractable by acetone and which had been produced during 2 days. Treatment with such excess amounts of T₄ during the early postnatal period significantly reduced the production of sebum in both male and female rats when compared with control rats and with rats deprived of food early in life. The thyroid, the pituitary gland, the testes and the seminal vesicles were significantly smaller but the weights of the ovaries and uteri remained relatively unaffected. There was a similar ratio of sex difference in the rate of sebum secretion irrespective of treatment. It is suggested that a reduction of sebaceous response in rats made thyrotoxic with large doses of T₄ early in life was probably due to a decreased secretion of thyroid hormone which is required to maintain normal activity of the sebaceous glands.