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Bromocriptine increased the concentration of prolactin in oestrogen-induced tumours of the rat pituitary gland. Prolactinaemia was significantly reduced and at the same time there was a considerable decrease in the weight of the tumour, in the incorporation of tritiated thymidine into DNA and in the activity of DNA polymerase a. The results suggested that the intracellular content of prolactin controls cell proliferation in this experimental tumour. A hypothalamic disorder is proposed as the primary cause of these tumours.

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				G. Diaz-Torga, A. G. Iglesias, R. Achaval-Zaia, C. Libertun, and D. Becu-Villalobos Angiotensin II-induced Ca2+ mobilization and prolactin release in normal and hyperplastic pituitary cells Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E534 - E540. [Abstract] [Full Text] [PDF]