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Progesterone production was assessed following short-term incubations of luteal cell suspensions prepared from tissue samples of human corpora lutea obtained at specific times throughout the luteal phase of the menstrual cycle. Luteal cells responded rapidly and sensitively to human chorionic gonadotrophin (HCG; concentration required for 50% maximum response, 0·1–1·0 i.u./ml) with a maximum level of response (five- to tenfold higher than basal production) similar to that elicited by human LH or N⁶,0²-dibutyryl cyclic AMP. In the absence of gonadotrophin or in the presence of sub-maximal (but not maximal) concentrations of HCG, progesterone production by mid-luteal phase cells was stimulated by prostaglandin F₂ (1 µmol/l), an effect not observed during the late-luteal phase. L-Adrenaline and L-isoprenaline failed to elicit significant increases in the level of progesterone production.

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				D. Ghosh, S. Sachdev, M. Hannink, and R. M. Roberts Coordinate Regulation of Basal and Cyclic 5'-Adenosine Monophosphate (cAMP)-Activated Expression of Human Chorionic Gonadotropin-{alpha} by Ets-2 and cAMP-Responsive Element Binding Protein Mol. Endocrinol., April 1, 2005; 19(4): 1049 - 1066. [Abstract] [Full Text] [PDF]