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Replacement of the 3'-halogen of the tri-iodothyronine (T₃) molecule by a propyl-group produces a thyromimetic analogue, 3'-isopropyl-3,5-di-iodo-l-thyronine (T₂iPr), with high biological potency. A serum thyroid-stimulating hormone (TSH) suppression test with one single intraperitoneal injection of 3 or 30 nM-T₃ or T₂iPr or with 30 or 300 nM-thyroxine (T₄) per kg body weight was performed on 56 adult male Lewis rats which were maintained for 3 weeks on an iodine-deficient diet containing 0·2% 6n-propyl-2-thiouracil (PTU). Blood was withdrawn from each rat by cardiac puncture 24 h before and 3, 7, 24 and 48 h after application of the iodothyronines.

Raised serum levels of TSH, due to the treatment with PTU, were significantly reduced within 3 h of treatment with 30 nM-T₃, 300 nM-T₄, 3 or 30 nM-T₂iPr and they remained low throughout the observation period. Treatment with 3 nM-T₃ or 30 nM-T₄ per kg body weight was less effective. Pituitary concentrations of growth hormone, TSH, prolactin and FSH were significantly reduced by the treatment with PTU. There was also a slight, but insignificant reduction of pituitary concentrations of LH. Treatment with T₃, T₄ or T₂iPr stimulated the reaccumulation of growth hormone, TSH, prolactin, LH and FSH in the pituitary gland.

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				J. J. Buzzard, J. R. Morrison, M. K. O'Bryan, Q. Song, and N. G. Wreford Developmental Expression of Thyroid Hormone Receptors in the Rat Testis Biol Reprod, March 1, 2000; 62(3): 664 - 669. [Abstract] [Full Text]