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Journal of Endocrinology (1980) 87, 279-283    DOI: 10.1677/joe.0.0870279
© 1980 Society for Endocrinology
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ACTIVATION OF SEXUAL BEHAVIOUR IN CASTRATED RATS WITH THE SYNTHETIC ANDROGEN 17β-HYDROXY-17{alpha}-METHYL-ESTRA-4,9,11-TRIENE-3-ONE (R 1881)

 P. SÖDERSTEN and J. -Å. GUSTAFSSON

Castrated sexually inactive rats were treated with the synthetic androgen 17β-hydroxy-17{alpha}-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R 1881), testosterone benzoate (TB), 5{alpha}-dihydrotestosterone benzoate (DHTB) or oestradiol benzoate (OB) and tested for sexual behaviour. The synthetic androgen, R 1881, was as potent as TB in stimulating sexual behaviour and OB stimulated all aspects of copulatory behaviour but DHTB had no significant effect. The synthetic androgen, R 1881, is not metabolized by target cells and rapid metabolism could explain the failure of DHTB to stimulate sexual behaviour.






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