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Dispersed pituitary cells obtained from female rats with regular oestrous cycles were suspended in Bio-Gel columns and perfused with pulses of luteinizing hormone releasing hormone (LH-RH). There was a close relationship between the amount of LH released and the concentration of LH-RH in the perfusate. It was not possible to elicit the priming effect of LH-RH, but the LH-response changed markedly during the oestrous cycle in a manner similar to that seen in vivo; i.e. the responses of cells prepared from rats killed at pro-oestrus were much greater than the responses of cells prepared from rats killed on other days of the cycle. A similar change in responsiveness was obtained when the columns were perfused with 60 mmol K⁺/1, suggesting that at least part of the increase in pituitary responsiveness that occurs at pro-oestrus is not dependent upon changes in specific receptors for LH-RH.

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				J. F. Todd, C. J. Small, K. O. Akinsanya, S. A. Stanley, D. M. Smith, and S. R. Bloom Galanin Is a Paracrine Inhibitor of Gonadotroph Function in the Female Rat Endocrinology, October 1, 1998; 139(10): 4222 - 4229. [Abstract] [Full Text] [PDF]