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Journal of Endocrinology (1981) 90, 421-431    DOI: 10.1677/joe.0.0900421
© 1981 Society for Endocrinology
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ANDROGEN AND OESTROGEN BINDING IN CYTOSOLS OF HUMAN OVARIAN TUMOURS

 T. C. HAMILTON, P. DAVIES and K. GRIFFITHS

The specific retention of androgens and oestrogens by cytoplasmic components of human ovarian tumours was investigated. High-affinity, low-capacity binding of androgens was observed in 88% of tumour specimens and oestrogen binding in 32%. Retention of oestrogens did not occur in the absence of androgen binding. The androgen-binding component, of sedimentation coefficient 7·5–8·5S, showed specificity for 5{alpha}-dihydrotestosterone and 17β-hydroxy-17{alpha}-methyl-estra-4,9,11-trien-3-one (R1881). In some instances, competition for R1881-binding sites indicated the presence of progesterone receptor-like binding. The data presented suggest strongly the existence of androgen and oestrogen receptors in some ovarian tumours and may be relevant to histopathological classification and therapeutic rationales.




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