HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MARKOFF, E. Articles by HANDWERGER, S. Search for Related Content PubMed Articles by MARKOFF, E. Articles by HANDWERGER, S.

The effects of extracellular osmolality and ions on the secretion of prolactin were examined in human decidual explants incubated for 4 h in modified Krebs–Ringer buffer. Explants incubated in media made hypersomotic (280–336 mOSM/kg) with sodium, lithium or mannitol or in media made hypo-osmotic (280–224 mOSM/kg) by decreasing the sodium concentration secreted the same amount of prolactin as explants incubated in control medium (280 mOSM/kg). Explants incubated in calcium-deficient medium secreted 64 ± 8% (P0·001) less prolactin than controls (1·65 mmol Ca²⁺/1). Secretion was restored to control values by the addition of calcium (0·33 mmol/l) or barium (0·5, 1·0 or 2·0 mmol/l) to the medium. Prolactin secretion was unaffected by higher than control extracellular calcium concentrations, calcium ionophore A23187 [GenBank] (10^–6, 10^–9 mol/l) or lanthanum (0·5, 1·0 or 2·0 mmol/l). Changes in extracellular magnesium (0–20 mmol/l), potassium (0–55 mmol/l) or bicarbonate (0–32 mmol/l) had no effect on prolactin secretion. These results indicate that marked changes in extracellular osmolality and concentrations of sodium, magnesium and bicarbonate have no effects on decidual prolactin secretion. Calcium, however, is essential for the basal secretion of decidual prolactin.

This article has been cited by other articles:

				M. Zinger, M. McFarland, and N. Ben-Jonathan Prolactin Expression and Secretion by Human Breast Glandular and Adipose Tissue Explants J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 689 - 696. [Abstract] [Full Text] [PDF]