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Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)₂D₃) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)₂D₃ and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)₂D₃ and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)₂D₃ which are responsible for the enhanced intestinal calcium absorption.

This article has been cited by other articles:

				M. Thiede and G. Rodan Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue Science, October 14, 1988; 242(4876): 278 - 280. [Abstract] [PDF]