JOE Society for Endocrinology Archive
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Endocrinology (1982) 95, 321-NP    DOI: 10.1677/joe.0.0950321
© 1982 Society for Endocrinology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McDowell, I. F. W.
Right arrow Articles by Charlton, H. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by McDowell, I. F. W.
Right arrow Articles by Charlton, H. M.

Characterization of the pituitary gonadotroph cells of hypogonadal (hpg) male mice: comparison with normal mice

 I. F. W. McDowell, J. F. Morris and H. M. Charlton

Hypogonadal (hpg) mice lack hypothalamic luteinizing hormone releasing hormone (LH-RH). Gonadotrophs from male hpg mice have been identified by immunocytochemistry for LH and quantitative electron microscopy allied with radioimmunoassay of the gonadotrophins. In comparison with those of normal mice, gonadotrophs in male hpg animals are less numerous and smaller, with less cytoplasm and rough endoplasmic reticulum and a smaller Golgi apparatus. They have fewer granules, especially those of larger (> 210 nm) diameter. Thus, in the absence of LH-RH, gonadotrophs can differentiate but remain relatively inactive.




This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
M. A. Lawson, R. Tsutsumi, H. Zhang, I. Talukdar, B. K. Butler, S. J. Santos, P. L. Mellon, and N. J. G. Webster
Pulse Sensitivity of the Luteinizing Hormone {beta} Promoter Is Determined by a Negative Feedback Loop Involving Early Growth Response-1 and Ngfi-A Binding Protein 1 and 2
Mol. Endocrinol., May 1, 2007; 21(5): 1175 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Zhang, J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon, and N. J. G. Webster
Activin Modulates the Transcriptional Response of LssT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation
Mol. Endocrinol., November 1, 2006; 20(11): 2909 - 2930.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. J. Pask, H. Kanasaki, U. B. Kaiser, P. M. Conn, J. A. Janovick, D. W. Stockton, D. L. Hess, M. J. Justice, and R. R. Behringer
A Novel Mouse Model of Hypogonadotrophic Hypogonadism: N-Ethyl-N-Nitrosourea-Induced Gonadotropin-Releasing Hormone Receptor Gene Mutation
Mol. Endocrinol., April 1, 2005; 19(4): 972 - 981.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. B. Seminara, S. Messager, E. E. Chatzidaki, R. R. Thresher, J. S. Acierno Jr., J. K. Shagoury, Y. Bo-Abbas, W. Kuohung, K. M. Schwinof, A. G. Hendrick, et al.
The GPR54 Gene as a Regulator of Puberty
N. Engl. J. Med., October 23, 2003; 349(17): 1614 - 1627.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. E. Olson and M. G. Rosenfeld
Perspective: Genetic and Genomic Approaches in Elucidating Mechanisms of Pituitary Development
Endocrinology, June 1, 2002; 143(6): 2007 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. J. O'Shaughnessy, P. Baker, U. Sohnius, A.-M. Haavisto, H. M. Charlton, and I. Huhtaniemi
Fetal Development of Leydig Cell Activity in the Mouse Is Independent of Pituitary Gonadotroph Function
Endocrinology, March 1, 1998; 139(3): 1141 - 1146.
[Abstract] [Full Text] [PDF]


HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Society for Endocrinology.