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The cover depicts a three-dimensional computer graphic of a snail brain showing neurosecretions, in a study on the effect of light on snail biorhythms. Colour variations (yellow, red, white) show varying levels of neurosecretion. Hastings et al. review in this issue presents an overview of the developments in our understanding of the fundamental mechanisms of the biological clocks that drive endocrine and other daily rhythms and applies this knowledge to understand what happens to our health and well-being when the body's clockwork goes wrong. Credit: H Raguet/Eurelios/Science Photo Library

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