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The cover shows a computer model of a heterotrimeric G protein complex. α - Helices are red and β sheets are yellow. G proteins are molecular switches involved in signal transduction and heterotrimeric proteins relay signals from cell surface receptors to their effector, including ion channels and enzymes, within a cell. In this issue, Szidonya et al. review the data that supports the concept of oligomerization of G protein coupled receptors and the most important arguments against it. Credit: LAGUNA DESIGN/Science Photo Library

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