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The cover shows a coloured scanning electron microscope of a resin cast of blood vessels in connective tissue. The cast was made by injecting resin into the blood vessels and the surrounding tissues were then chemically ingested. In this issue's review, Villar et al. discuss sex differences in endothelium-derived hyperpolarising factor biology and how sex hormones can modulate EDHF responses. They also review the implication of sex hormone-dependent regulation of EDHF in inflammatory processes, platelet function and repair after vascular damage, each of which have a critical role in several aspects of the pathogenesis of cardiovascular disease. Magnification: X 70 at 6 X 7 cm size Credit: Susumu Nishinaga/Science Photo Library

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